Potassium Chloride

Brand names: 4 Kids Canker Sore Soothing Dots, ALPHA SH, ARNISPORT, AmazaPet, Amazapet, Bio-Combination 10, Bio-Combination 13, Bio-Combination 14, Bio-Combination 17, Bio-Combination 22, Bio-Combination 28, Bio-Combination 4, Bio-Combination 5, Bio-Combination 6, Bio-Combination 9, Bioplasma, Cell Salts Combination, DANDRUFF, DIAMITE, DIAMITE 12, ECZEMA, Effervescent Potassium Chloride, Hendel Schuessler Cell Salts, Homeopathic Ear Ache Formula, K-DUR, K-TAB, K-Tab, KALI MURIATICUM, KALIUM MURIATICUM 6X, KLOR-CON, KLOR-CON M, Kali Mur, Kali muriaticum, Klor Con M, Klor-Con, Klor-Con M, Klor-Con M10, Klor-Con M20, Klor-Con Sprinkle, MUCUSgone, Melange combination, Micro-K 10 Extencaps, Micro-K Extencaps, OHM Mucus Relief, Potassium Chloride Extended-Release, Potassium chloride extended release, Rxhomeo Homeopathic Combo, Rxhomeo Homeopathic Combo 19, Rxhomeo Homeopathic Combo 24, Skin Dr, Slow Release CMPK Bolus, Stamina, Thermotabs Buffered Salt Supplement, Tonsin, Umcka Allergy and Sinus, Wellness Earache, Yeast Gard Advanced, Young Adult ClearAc, Potassium chloride, Potassium Chloride, POTASSIUM CHLORIDE, potassium chloride, POTASSIUM CHLORIDE EXTENDED RELEASE, Kali Muriaticum Kit Refill, POKONZA, Potassium Chloride for Oral Solution, POKONZA potassium chloride, Sore Throat 911, D-125

Boxed warning

Highly Concentrated

Warnings

BOXED WARNING: "Because of reports of intestinal and gastric ulceration and bleeding with extended-release potassium chloride preparations, these drugs should be reserved for those patients who cannot tolerate or refuse to take liquid or effervescent potassium preparations, or for patients in whom these products are not appropriate." Contraindicated in hyperkalemia, which "can produce cardiac arrest," and in conditions predisposing to hyperkalemia; also contraindicated with gastrointestinal obstruction, delayed gastric emptying, or conditions slowing GI transit because of the ulcerogenic potential of concentrated potassium salts. Caution is advised with potassium-sparing diuretics, ACE inhibitors/ARBs, and in renal impairment.

Contraindications

4 CONTRAINDICATIONS Potassium chloride is contraindicated in patients on triamterene and amiloride. Concomitant use with triamterene and amiloride (4)

Overdose

10 OVERDOSAGE 10.1 Symptoms The administration of oral potassium salts to persons with normal excretory mechanisms for potassium rarely causes serious hyperkalemia. However, if excretory mechanisms are impaired, potentially fatal hyperkalemia can result [see CONTRAINDICATIONS and WARNINGS ] . It is important to recognize that hyperkalemia is usually asymptomatic and may be manifested only by an increased serum potassium concentration (6.5 to 8.0 mEq/L) and characteristic electrocardiographic changes (peaking of T-waves, loss of P-wave, depression of S-T segment and prolongation of the QT interval). Late manifestations include muscle paralysis and cardiovascular collapse from cardiac arrest (9 to 12 mEq/L). 10.2 Treatment Treatment measures for hyperkalemia include the following: Elimination of foods and medications containing potassium and of any agents with potassium-sparing properties. Intravenous administration of 300 to 500 mL/hr of 10% dextrose solution containing 10 to 20 units of crystalline insulin per 1,000 mL. Correction of acidosis, if present, with intravenous sodium bicarbonate. Use of exchange resins, hemodialysis or peritoneal dialysis. In treating hyperkalemia, it should be recalled that in patients who have been stabilized on digitalis, too rapid a lowering of the serum potassium concentration can produce digitalis toxicity. The extended release feature means that absorption and toxic effects may be delayed for hours. Consider standard measures to remove any unabsorbed drug.

Drug interactions

7 DRUG INTERACTIONS Triamterene and amiloride: Concomitant use is contraindicated (7.1) Renin-angiotensin-aldosterone inhibitors: Monitor for hyperkalemia (7.2) Nonsteroidal anti-inflammatory drugs: Monitor for hyperkalemia (7.3) 7.1 Triamterene or amiloride Use with triamterene or amiloride can produce severe hyperkalemia. Concomitant use is contraindicated [see Contraindications (4) ] . 7.2 Renin-angiotensin-aldosterone Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production. Closely monitor potassium in patients on concomitant RAAS inhibitors. 7.3 Nonsteroidal Anti-inflammatory Drugs (NSAIDs) NSAIDS may produce potassium retention by reducing renal synthesis of prostaglandin E and imparing the renin-angiotensin system. Closely monitor potassium in patients on concomitant NSAIDs.

Uses

Extended-release potassium chloride tablets are indicated for "treatment of patients with hypokalemia with or without metabolic alkalosis," including digitalis intoxication and hypokalemic familial periodic paralysis, and for "prevention of hypokalemia" in patients at risk, such as those on digitalis who would be endangered by even transient hypokalemia, or those with inadequate dietary potassium intake.

Dosage forms & strengths

C42910 C42917 C42985 Capsule Capsule, Extended Release Tablet Tablet, Chewable Tablet, Extended Release Tablet, Film Coated, Extended Release Tablet, Orally Disintegrating INJECTION, SOLUTION, CONCENTRATE POWDER, FOR SOLUTION CAPSULE, EXTENDED RELEASE TABLET, FILM COATED, EXTENDED RELEASE TABLET, EXTENDED RELEASE SOLUTION POWDER INJECTION CAPSULE, COATED, EXTENDED RELEASE PELLET INJECTION, SOLUTION CAPSULE GRANULE TABLET FOR SOLUTION CRYSTAL LIQUID LOTION

ACONITUM NAPELLUS 30 [hp_C] ATROPA BELLADONNA 30 [hp_C] CAPSICUM 30 [hp_C] CHAMOMILE 30 [hp_C] FERRUM PHOSPHORICUM 30 [hp_C] POTASSIUM CHLORIDE 30 [hp_C] ALTHAEA OFFICINALIS ROOT 2 [hp_X] ARSENIC TRIOXIDE 30 [hp_C] INULA HELENIUM ROOT 2 [hp_X] POTASSIUM CHLORIDE 6 [hp_X] MAGNESIUM PHOSPHATE, DIBASIC TRIHYDRATE 8 [hp_X] PHOSPHORUS 30 [hp_C] ANHYDROUS CITRIC ACID 0.77 g SORBITOL 0.45 g SODIUM BENZOATE 0.077 g POLYETHYLENE GLYCOL 8000 0.041 g SACCHARIN SODIUM ANHYDROUS 0.04 g POTASSIUM CHLORIDE 1.25 g POTASSIUM BICARBONATE 0.7 g LYSINE HYDROCHLORIDE 1.5 g ANTIMONY TRISULFIDE 6 [hp_C] ANTIMONY POTASSIUM TARTRATE 6 [hp_C] CHELIDONIUM MAJUS 6 [hp_X] FERROSOFERRIC PHOSPHATE 6 [hp_X] POTASSIUM DICHROMATE 12 [hp_X] POTASSIUM CARBONATE 30 [hp_C] POTASSIUM SULFATE 6 [hp_X] MARRUBIUM VULGARE 9 [hp_C] CALCIUM FLUORIDE 12 [hp_C] TRIBASIC CALCIUM PHOSPHATE 12 [hp_C] CALCIUM SULFATE ANHYDROUS 12 [hp_C] FERROSOFERRIC PHOSPHATE 12 [hp_C] POTASSIUM CHLORIDE 12 [hp_C] DIBASIC POTASSIUM PHOSPHATE 12 [hp_C] POTASSIUM SULFATE 12 [hp_C] MAGNESIUM PHOSPHATE, DIBASIC TRIHYDRATE 12 [hp_C] SODIUM CHLORIDE 12 [hp_C] SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE 12 [hp_C] SODIUM SULFATE 12 [hp_C] SILICON DIOXIDE 12 [hp_C] CALCIUM FLUORIDE 12 [hp_X] CALCIUM PHOSPHATE 12 [hp_X] CALCIUM SULFATE 12 [hp_X] FERRUM PHOSPHORICUM 12 [hp_X] POTASSIUM CHLORIDE 12 [hp_X] POTASSIUM PHOSPHATE, DIBASIC 12 [hp_X] POTASSIUM SULFATE 12 [hp_X] MAGNESIUM PHOSPHATE, DIBASIC 12 [hp_X] SODIUM CHLORIDE 12 [hp_X] SODIUM PHOSPHATE, DIBASIC 12 [hp_X] SODIUM SULFATE 12 [hp_X] SILICON DIOXIDE 12 [hp_X] CALCIUM FLUORIDE 3 [hp_X] POTASSIUM CHLORIDE 3 [hp_X] SODIUM CHLORIDE 6 [hp_X] TRIBASIC CALCIUM PHOSPHATE 3 [hp_X] CALCIUM SULFATE ANHYDROUS 3 [hp_X] FERROSOFERRIC PHOSPHATE 3 [hp_X] POTASSIUM PHOSPHATE, DIBASIC 3 [hp_X] POTASSIUM SULFATE 3 [hp_X] MAGNESIUM PHOSPHATE, DIBASIC TRIHYDRATE 3 [hp_X] SODIUM CHLORIDE 3 [hp_X] SODIUM SULFATE 3 [hp_X] SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE 3 [hp_X] SILICON DIOXIDE 3 [hp_X] FERROSOFERRIC PHOSPHATE 12 [hp_X] CALCIUM FLUORIDE 6 [hp_X] CALCIUM PHOSPHATE 6 [hp_X] CALCIUM SULFATE 6 [hp_X] FERRUM PHOSPHORICUM 5 [hp_X] POTASSIUM CHLORIDE 4 [hp_X] MAGNESIUM PHOSPHATE, DIBASIC 3 [hp_X] SODIUM PHOSPHATE, DIBASIC 3 [hp_X] SILICON DIOXIDE 6 [hp_X] FERRUM PHOSPHORICUM 6 [hp_X] POTASSIUM PHOSPHATE, DIBASIC 6 [hp_X] MAGNESIUM PHOSPHATE, DIBASIC 6 [hp_X] SODIUM PHOSPHATE, DIBASIC 6 [hp_X] SODIUM SULFATE 6 [hp_X] TRIBASIC CALCIUM PHOSPHATE 6 [hp_X] CALCIUM SULFATE ANHYDROUS 6 [hp_X] DIBASIC POTASSIUM PHOSPHATE 6 [hp_X] CALCIUM PHOSPHATE, DIBASIC, ANHYDROUS 6 [hp_X] SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE 6 [hp_X] MAGNESIUM PHOSPHATE, DIBASIC TRIHYDRATE 6 [hp_X] CAPSICUM 6 [hp_X] VERBASCUM THAPSUS 6 [hp_X] ACONITUM NAPELLUS 30 [hp_X] ATROPA BELLADONNA 30 [hp_X] OYSTER SHELL CALCIUM CARBONATE, CRUDE 30 [hp_X] PULSATILLA PRATENSIS 30 [hp_X] DIBASIC CALCIUM PHOSPHATE DIHYDRATE 10.3 g MAGNESIUM OXIDE 3 g POTASSIUM CHLORIDE 0.75 1 GALIUM APARINE 3 [hp_X] POTASSIUM CHLORIDE 6 [hp_C] POTASSIUM SULFATE 6 [hp_C] SODIUM CHLORIDE 6 [hp_C] URTICA URENS 6 [hp_C] HYPERICUM PERFORATUM 6 [hp_X] RUTA GRAVEOLENS FLOWERING TOP 6 [hp_X] LEDUM PALUSTRE TWIG 6 [hp_X] BELLIS PERENNIS 6 [hp_X] FERRUM PHOSPHORICUM 3 [hp_X] ARNICA MONTANA 30 [hp_X] INULA HELENIUM ROOT 2 [hp_X] / ALTHAEA OFFICINALIS ROOT 2 [hp_X] / MAGNESIUM PHOSPHATE 6 [hp_X] / POTASSIUM CHLORIDE 6 [hp_X] / ARSENIC TRIOXIDE 30 [hp_C] / PHOSPHORUS 30 [hp_C] INULA HELENIUM ROOT 2 [hp_X] / ALTHAEA OFFICINALIS ROOT 2 [hp_X] / MAGNESIUM PHOSPHATE, DIBASIC TRIHYDRATE 6 [hp_X] / POTASSIUM CHLORIDE 6 [hp_X] / ARSENIC TRIOXIDE 30 [hp_C] / PHOSPHORUS 30 [hp_C] LACTOSE 100 mg URTICA URENS 3 [hp_X] NICKEL SULFATE HEXAHYDRATE 3 [hp_X] POTASSIUM BROMIDE 1 [hp_X] POTASSIUM CHLORIDE 1 [hp_X] CALCIUM SULFIDE 3 [hp_X] POTASSIUM DICHROMATE 3 [hp_X] SULFUR 1 [hp_X] OYSTER SHELL CALCIUM CARBONATE, CRUDE 6 [hp_X] COLLINSONIA CANADENSIS ROOT 3 [hp_X] PELARGONIUM SIDOIDES ROOT 1 [hp_X] HYDRASTIS CANADENSIS WHOLE 6 [hp_X] SANGUINARIA CANADENSIS ROOT 6 [hp_X] PULSATILLA VULGARIS 3 [hp_X] PULSATILLA VULGARIS 6 [hp_X] POTASSIUM SULFATE 1 [hp_X] SODIUM CHLORIDE 1 [hp_X] OYSTER SHELL CALCIUM CARBONATE, CRUDE 3 [hp_X] POTASSIUM CHLORIDE 10 meq POTASSIUM CHLORIDE 1125 mg POTASSIUM CHLORIDE 1500 mg POTASSIUM CHLORIDE 20 meq POTASSIUM CHLORIDE 30 [hp_X] POTASSIUM CHLORIDE 600 mg POTASSIUM CHLORIDE 750 mg POTASSIUM CHLORIDE 8 meq Potassium Chloride 1125 mg Potassium Chloride 1500 MILLIGRAM in 1 TABLET Potassium Chloride 1500 mg Potassium Chloride 600 mg Potassium Chloride 750 MILLIGRAM in 1 TABLET Potassium Chloride 750 mg SAMBUCUS NIGRA FLOWERING TOP 3 [hp_X] POTASSIUM DICHROMATE 6 [hp_X] ALLIUM CEPA WHOLE 3 [hp_X] PULSATILLA PRATENSIS 3 [hp_X] CALCIUM SULFIDE 6 [hp_X] MERCURIUS SOLUBILIS 10 [hp_X] GOLDENSEAL 6 [hp_X] SILICON DIOXIDE 30 [hp_X] SULFUR 30 [hp_X] POTASSIUM DICHROMATE 30 [hp_X] POTASSIUM BROMIDE 30 [hp_X] ARSENIC TRIOXIDE 30 [hp_X] POTASSIUM CHLORIDE 9 [hp_X] ACTIVATED CHARCOAL 30 [hp_X] CALCIUM SULFIDE 12 [hp_X] SILVER NITRATE 6 [hp_X] ECHINACEA, UNSPECIFIED 6 [hp_X] Sodium Chloride 454 mg Potassium Chloride 30 mg TRIBASIC CALCIUM PHOSPHATE 12 [hp_X] potassium chloride 10 meq potassium chloride 1125 mg potassium chloride 1500 mg potassium chloride 20 meq potassium chloride 600 mg potassium chloride 750 mg POTASSIUM CHLORIDE 149 mg/mL POTASSIUM CHLORIDE 1.5 g/1.77g POTASSIUM CHLORIDE 750 mg/1 POTASSIUM CHLORIDE 1500 mg/1 POTASSIUM CHLORIDE 20 meq/15mL POTASSIUM CHLORIDE .87 kg/kg POTASSIUM CHLORIDE 1 kg/kg POTASSIUM CHLORIDE 100 kg/100kg POTASSIUM CHLORIDE 25 kg/25kg POTASSIUM CHLORIDE 29.8 mg/mL POTASSIUM CHLORIDE 40 meq/15mL POTASSIUM CHLORIDE 10 meq/1 POTASSIUM CHLORIDE 3 g/15mL POTASSIUM CHLORIDE 1 [hp_M]/[hp_M] POTASSIUM CHLORIDE 12 [hp_X]/12[hp_X] POTASSIUM CHLORIDE 30 [hp_X]/30[hp_X] POTASSIUM CHLORIDE 600 mg/1 POTASSIUM CHLORIDE 1.5 g/1.58g POTASSIUM CHLORIDE 200 meq/1000mL POTASSIUM CHLORIDE 20 meq/1 POTASSIUM CHLORIDE 40 meq/30mL POTASSIUM CHLORIDE 30 [hp_C]/30[hp_C] POTASSIUM CHLORIDE 7.46 g/1000mL POTASSIUM CHLORIDE 200 [hp_C]/1 POTASSIUM CHLORIDE 1125 mg/1 POTASSIUM CHLORIDE 1.125 g/1.185g POTASSIUM CHLORIDE 20 meq/30mL POTASSIUM CHLORIDE 10 meq/100mL POTASSIUM CHLORIDE 1.5 g/15mL POTASSIUM CHLORIDE 6 [hp_C]/6[hp_C] POTASSIUM CHLORIDE 6 [hp_X]/1 POTASSIUM CHLORIDE 10 meq/10meq POTASSIUM CHLORIDE 7.45 mg/mL POTASSIUM CHLORIDE 15 [hp_C]/15[hp_C] POTASSIUM CHLORIDE 200 [kp_C]/200[kp_C] POTASSIUM CHLORIDE 2 meq/mL POTASSIUM CHLORIDE 8 meq/1 POTASSIUM CHLORIDE 3 g/3.16g POTASSIUM CHLORIDE 50 kg/50kg POTASSIUM CHLORIDE 100 mg/1 POTASSIUM CHLORIDE 10 meq/15mL POTASSIUM CATION .05 [hp_X]/mL POTASSIUM CHLORIDE 1.5 g/1.54g POTASSIUM CHLORIDE 12 [hp_C]/12[hp_C] POTASSIUM CHLORIDE 1.5 g/1 POTASSIUM CHLORIDE 14.9 mg/mL POTASSIUM CHLORIDE .75 g/.79g POTASSIUM CHLORIDE 20 meq/100mL POTASSIUM CHLORIDE 1.5 g/1.56g POTASSIUM CHLORIDE 400 meq/1000mL POTASSIUM CHLORIDE 14.9 g/100mL POTASSIUM CHLORIDE 14.9 g/1000mL POTASSIUM CHLORIDE 10 meq/50mL POTASSIUM CHLORIDE 20 meq/50mL POTASSIUM CHLORIDE 40 meq/100mL POTASSIUM CHLORIDE 3 g/30mL POTASSIUM CHLORIDE 9 [hp_C]/9[hp_C] POTASSIUM CHLORIDE 1.5 g/1.57g POTASSIUM CHLORIDE 29.8 g/1000mL POTASSIUM CHLORIDE 6 [hp_X]/mL

2 DOSAGE AND ADMINISTRATION Monitor serum potassium and adjust dosages accordingly (2.1) If serum potassium is less than 2.5 mEq/L, use intravenous potassium instead of oral supplementation (2.1) Take with meals and with a glass of water or other liquid. Swallow tablets whole without crushing, chewing or sucking. (2.1) Treatment of hypokalemia : Doses range from 40 to 100 mEq/day in divided doses. Limit doses to 40 mEq per dose. (2.2) Prevention of hypokalemia : Typical dose is 20 mEq per day. (2.2) 2.1 Administration and Monitoring If serum potassium concentration is less than 2.5 mEq/L, use intravenous potassium instead of oral supplementation. Monitoring Monitor serum potassium and adjust dosages accordingly. Monitor serum potassium periodically during maintenance therapy to ensure potassium remains in desired range. The treatment of potassium depletion, particularly in the presence of cardiac disease, renal disease, or acidosis, requires careful attention to acid-base balance, volume status, electrolytes, including magnesium, sodium, chloride, phosphate, and calcium, electrocardiograms, and the clinical status of the patient. Correct volume status, acid-base balance, and electrolyte deficits as appropriate. Administration Take potassium chloride extended-release tablets with meals and with a glass of water or other liquid. Do not take potassium chloride extended-release tablets on an empty stomach because of its potential for gastric irritation [see Warnings and Precautions (5.1) ] . Swallow tablets whole without crushing, chewing or sucking. 2.2 Dosing Dosage must be adjusted to the individual needs of each patient. Dosages greater than 40 mEq per day should be divided such that no more than 40 mEq is given in a single dose. Treatment of Hypokalemia: Typical dose range is 40 to 100 mEq per day. Maintenance or Prophylaxis: Typical dose range is 20 mEq per day.

Ingredients

Active:

INGREDIENTS ACTIVE Kalium muriaticum 6x, 12x, 30x INACTIVE 20% alcohol in purified water.

Inactive:

INACTIVE 20% alcohol in purified water.