E 221 Pill — WHITE OVAL, 19mm — Metformin

Imprint	E / 221
Colour	WHITE
Shape	OVAL
Size	19
Strength	METFORMIN HYDROCHLORIDE 1000 mg
Dosage form	Tablet
Manufacturer	Aphena Pharma Solutions - Tennessee, LLC
NDC	43353-936
Schedule	—
Availability	—
Ingredients	METFORMIN HYDROCHLORIDE[METFORMIN]

What does this imprint mean?

The imprint "E 221" is a code stamped or printed on the tablet or capsule by the manufacturer, used to identify the drug, its strength and the maker.

Active ingredient

Metformin

Uses and warnings

BOXED WARNING - LACTIC ACIDOSIS: Postmarketing cases of metformin-associated lactic acidosis have caused death, hypothermia, hypotension, and resistant bradyarrhythmias. Symptoms included malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Risk factors include renal impairment, certain drug combinations, age over 65, contrast imaging procedures, surgery, hypoxic states, excessive alcohol, and hepatic impairment. If lactic acidosis is suspected, discontinue immediately and seek prompt hemodialysis. Additional Warnings: - Vitamin B12 deficiency may occur; monitor hematologic parameters annually and B12 levels every 2-3 years - Increased hypoglycemia risk when combined with insulin or insulin secretagogues - No conclusive evidence of macrovascular risk reduction

Metformin hydrochloride extended-release tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Read the full drug profile →

How to identify this pill

• Check the imprint matches exactly: "E 221".
• Confirm the colour (WHITE) and shape (OVAL).
• Compare the size (19) against a ruler if possible.
• When in doubt, confirm with a pharmacist before taking any medication.

E 221 Pill — WHITE OVAL, 19mm — Metformin

What does this imprint mean?

Active ingredient

Uses and warnings

How to identify this pill

Similar-looking pills

Other pills of Metformin

Official references