445 Pill — YELLOW ROUND, 9mm — Donepezil

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Imprint	445
Colour	YELLOW
Shape	ROUND
Size	9
Strength	DONEPEZIL HYDROCHLORIDE 10 mg
Dosage form	Tablet, Film Coated
Manufacturer	REMEDYREPACK INC.
NDC	52125-492
Schedule	—
Availability	—
Ingredients	DONEPEZIL HYDROCHLORIDE[DONEPEZIL]

What does this imprint mean?

The imprint "445" is a code stamped or printed on the tablet or capsule by the manufacturer, used to identify the drug, its strength and the maker.

Active ingredient

Donepezil

Uses and warnings

Contraindicated in patients with "known hypersensitivity to donepezil hydrochloride or to piperidine derivatives." Key warnings: as a cholinesterase inhibitor, it is "likely to exaggerate succinylcholine-type muscle relaxation during anesthesia"; may have "vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block"; "ARICEPT can cause vomiting," with an associated risk of gastrointestinal bleeding, particularly at higher doses; weight loss has been reported with the 23 mg dose; potential to cause seizures in susceptible patients.

ARICEPT (donepezil hydrochloride) "is indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's disease."

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