Nortriptyline

Brand names: NORTRIPTYLINE HCI, NORTRIPTYLINE HYDROCHLORIDE, Nortriptyline HCL, Nortriptyline Hydrochloride, PAMELOR

Warnings

BOXED WARNING: "Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders," with age-stratified rates (additional cases in patients under 25, fewer cases in adults 25 and older). Additional warnings cover close monitoring for "anxiety, agitation, panic attacks, insomnia...hostility, aggressiveness, impulsivity, akathisia"; cardiovascular caution due to tachycardia/conduction effects; "potentially life-threatening serotonin syndrome" with serotonergic drugs or MAOIs; avoidance in Brugada syndrome; and angle-closure glaucoma risk from pupillary dilation.

Uses

Pamelor (nortriptyline HCl) is indicated for the relief of symptoms of depression. Endogenous depressions are more likely to be alleviated than are other depressive states." "Nortriptyline hydrochloride is not approved for use in pediatric patients.

Dosage forms & strengths

Capsule
NORTRIPTYLINE HYDROCHLORIDE 10 mg NORTRIPTYLINE HYDROCHLORIDE 25 mg NORTRIPTYLINE HYDROCHLORIDE 50 mg NORTRIPTYLINE HYDROCHLORIDE 75 mg Nortriptyline Hydrochloride 10 mg Nortriptyline Hydrochloride 25 mg Nortriptyline Hydrochloride 50 mg Nortriptyline Hydrochloride 75 mg

All identified pills

Side effects

Anticholinergic effects include "dry mouth...blurred vision...constipation, paralytic ileus; urinary retention." Cardiovascular effects include hypotension, hypertension, tachycardia, palpitations, and arrhythmias. Psychiatric effects include "confusional states (especially in the elderly) with hallucinations, disorientation, delusions; anxiety, restlessness, agitation." Also reported: numbness, tingling, tremors, seizures, "nausea and vomiting, anorexia, epigastric distress, diarrhea," weight changes, drowsiness, weakness, headache, and alopecia.

Official source

DailyMed