Meclizine
Brand names: Antivert, BONINE, Bonine, CVS Motion Sickness Fast Melting, DRAMAMINE, DRAMAMINE - N, Dramamine Less Drowsy, Jet-Avert Motion Sickness Aid, Less Drowsy Formula Motion Sickness Relief, Less Drowsy Motion Sickness Relief, MECLIZINE HCL, MECLIZINE HYDROCHLORIDE, Meclizine 25, Meclizine HCL, Meclizine HCL 12.5 mg, Meclizine HCL 25 mg, Meclizine HCl, Meclizine HCl 25 mg, Meclizine Hydrochloride, Meclizine Hydrocloride, Meclizine hydrochloride, Medique Medi-Meclizine, Motion Relief - Less Drowsy Formula, Motion Sickness, Motion Sickness II, Motion Sickness Less Drowsy Formula, Motion Sickness Relief, Motion sickness, Motion-Time, NAUS-EASE, NausX, Rugby, Rugby Meclizine HCl, Rugby Travel Sickness, Rugby Travel SicknessMeclizine HCl, 25 mg Each (ANTIEMETIC), RugbyMeclizine HCl, 12.5 mg Each ANTIEMETIC, SEA-CALM, TRAV-L-TABS, TRAVEL SICKNESS MECLIZINE HCL, TRAVEL TIME, Travel Ease, Travel-Ease, Verticalm, Wal Dram, Wal-Dram 2 Quick-Dissolving, Welly Travel Medicine Kit, less drowsy motion sickness relief, meclinzine hydorchloride, motion sickness, motion sickness relief
Warnings
No boxed warning. "Meclizine hydrochloride tablets are contraindicated in patients with a hypersensitivity to meclizine or any of the inactive ingredients." Patients should be "warned of this possibility [drowsiness] and cautioned against driving a car or operating dangerous machinery," and the label advises avoiding alcoholic beverages while taking meclizine. It should be used cautiously in patients with asthma, glaucoma, or prostatic enlargement because of anticholinergic-like effects.
Contraindications
4 CONTRAINDICATIONS Meclizine hydrochloride tablets are contraindicated in patients with a hypersensitivity to meclizine or any of the inactive ingredients [see Adverse Reactions (6) and Description (11) ]. Meclizine hydrochloride tablets are contraindicated in patients with hypersensitivity to meclizine or any of the inactive ingredients ( 4 ).
Drug interactions
7 DRUG INTERACTIONS Coadministration of meclizine hydrochloride tablets with other CNS depressants, including alcohol, may result in increased CNS depression ( 7.1 ). CYP2D6 inhibitors: As meclizine is metabolized by CYP2D6, there is a potential for drug-drug interactions between meclizine hydrochloride tablets and CYP2D6 inhibitors ( 7.2 ). 7.1 CNS Depressants There may be increased CNS depression when meclizine hydrochloride tablets are administered concurrently with other CNS depressants, including alcohol [see Warnings and Precautions (5.1) ] . 7.2 CYP2D6 Inhibitors Based on in-vitro evaluation, meclizine is metabolized by CYP2D6. Therefore, there is a possibility for a drug interaction between meclizine hydrochloride tablets and CYP2D6 inhibitors. Therefore, monitor for adverse reactions and clinical effect accordingly.
Uses
"Meclizine hydrochloride tablets are indicated for the treatment of vertigo associated with diseases affecting the vestibular system in adults," typically dosed at 25 mg to 100 mg daily in divided doses.
Dosage forms & strengths
2 DOSAGE AND ADMINISTRATION Recommended dosage: 25 mg to 100 mg daily, in divided doses ( 2.1 ). Tablets: Swallow whole ( 2.2 ). 2.1 Recommended Dosage The recommended dosage is 25 mg to 100 mg daily administered orally, in divided doses, depending upon clinical response. 2.2 Administration Instructions Tablets: Meclizine hydrochloride tablets must be swallowed whole.
All identified pills
TCL086
YELLOW ROUND · Meclizine
11 manufacturers
TCL086
WHITE;YELLOW ROUND · Meclizine
3 manufacturers
TCL333
PINK ROUND · Meclizine
6 manufacturers
TL121
YELLOW OVAL · Meclizine
28 manufacturers
TL122
BLUE OVAL · Meclizine
10 manufacturers
WATSON 802
BLUE;WHITE OVAL · Meclizine
WATSON 803
WHITE;YELLOW OVAL · Meclizine
PINK ROUND · Meclizine
YELLOW ROUND · Meclizine
2 manufacturers
Side effects
Reported adverse reactions include "anaphylactic reaction, drowsiness, dry mouth, headache, fatigue, and vomiting. On rare occasions blurred vision has been reported."