Hydrochlorothiazide
Brand names: ATACAND HCT, Benazepril Hydrochloride and Hydrochlorothiazide, Diovan HCT, Enalapril Maleate and Hydrochlorothiazide, Lotensin HCT, Moexipril Hydrochloride and Hydrochlorothiazide, Valsartan and Hydrochlorothiazide, Ziac, benazepril hydrochloride and hydrochlorothiazide, bisoprolol fumarate and hydrochlorothiazide, Hydrochlorothiazide, HYDROCHLOROTHIAZIDE, hydrochlorothiazide, INZIRQO
Warnings
Key warnings include: - "Use with caution in severe renal disease" as thiazides may precipitate azotemia - Caution advised with impaired hepatic function due to risk of hepatic coma - Risk of systemic lupus erythematosus exacerbation reported - "Lithium generally should not be given with diuretics" due to toxicity risk - Potential electrolyte imbalances requiring monitoring (hypokalemia, hyponatremia, hypochloremic alkalosis)
Contraindications
CONTRAINDICATIONS Hydrochlorothiazide is contraindicated in patients with anuria. Hypersensitivity to this product or other sulfonamide derived drugs is also contraindicated.
Overdose
OVERDOSAGE The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. In the event of overdosage, symptomatic and supportive measures should be employed. Emesis should be induced or gastric lavage performed. Correct dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures. If required, give oxygen or artificial respiration for respiratory impairment. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established. The oral LD 50 of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat.
Drug interactions
Alcohol, barbiturates, or narcotics: potentiation of orthostatic hypotension may occur. Antidiabetic drugs: (oral agents and insulin) dosage adjustment of the antidiabetic drug may be required. Other antihypertensive drugs: additive effect or potentiation. Cholestyramine and colestipol resins: Cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively. Corticosteroid, ACTH: intensified electrolyte depletion, particularly hypokalemia. Pressor amines (e.g., norepinephrine): possible decreased response to pressor amines but not sufficient to preclude their use. Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine): possible increased responsiveness to the muscle relaxant. Lithium: generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and greatly increase the risk of lithium toxicity. Refer to the package insert for lithium preparations before use of such preparations with hydrochlorothiazide capsules. Non-steroidal anti-inflammatory drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. When hydrochlorothiazide capsules and non-steroidal anti-inflammatory agents are used concomitantly, the patients should be observed closely to determine if the desired effect of the diuretic is obtained. Drug/Laboratory Test Interactions: Thiazides should be discontinued before carrying out tests for parathyroid function (see PRECAUTIONS , General ).
Uses
Hydrochlorothiazide is indicated for edema management associated with congestive heart failure, hepatic cirrhosis, and corticosteroid/estrogen therapy, as well as edema from renal dysfunction. It's also used to manage hypertension "either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs."
Dosage forms & strengths
DOSAGE AND ADMINISTRATION For Control of Hypertension: The adult initial dose of hydrochlorothiazide capsules, USP is one capsule given once daily whether given alone or in combination with other antihypertensives. Total daily doses greater than 50 mg are not recommended.
All identified pills
WW 62
BLUE ROUND · Hydrochlorothiazide
8 manufacturers
WW 64
RED ROUND · Hydrochlorothiazide
6 manufacturers
WW256
ORANGE ROUND · Hydrochlorothiazide
2 manufacturers
WW257
ORANGE ROUND · Hydrochlorothiazide
Watson 424
GREEN ROUND · Hydrochlorothiazide
Watson 348
YELLOW ROUND · Hydrochlorothiazide
Watson 348
YELLOW ROUND · Hydrochlorothiazide
West ward
ORANGE ROUND · Hydrochlorothiazide
West ward
ORANGE ROUND · Hydrochlorothiazide
Westward 3125
BLUE CAPSULE · Hydrochlorothiazide
Westward 256
ORANGE ROUND · Hydrochlorothiazide
3 manufacturers
Westward 257
ORANGE ROUND · Hydrochlorothiazide
ZD18
WHITE CAPSULE · Hydrochlorothiazide
4 manufacturers
ZD19
WHITE CAPSULE · Hydrochlorothiazide
6 manufacturers
b 50
PINK ROUND · Hydrochlorothiazide
2 manufacturers
b 40
WHITE ROUND · Hydrochlorothiazide
2 manufacturers
b 47
YELLOW ROUND · Hydrochlorothiazide
2 manufacturers
debossedwith1251ononeside
YELLOW ROUND · Hydrochlorothiazide
2 manufacturers
debossedwith1252ononeside
YELLOW OVAL · Hydrochlorothiazide
debossedwith1253ononeside
PINK OVAL · Hydrochlorothiazide
2 manufacturers
heart 2875
ORANGE OVAL · Hydrochlorothiazide
heart 2876
ORANGE OVAL · Hydrochlorothiazide
TURQUOISE CAPSULE · Hydrochlorothiazide
PINK OVAL · Hydrochlorothiazide
WHITE OVAL · Hydrochlorothiazide
RED OVAL · Hydrochlorothiazide
2 manufacturers
GRAY OVAL · Hydrochlorothiazide
2 manufacturers
Side effects
Common side effects include hypokalemia, hyperglycemia, hyperuricemia, electrolyte imbalance, orthostatic hypotension, weakness, and gastrointestinal disturbances like nausea and diarrhea.