Estradiol

Brand names: ALTAVERA, ALYACEN 1/35, ALYACEN 7/7/7, AMABELZ, APRI, AUBRA, AUROVELA Fe, AVIANE, Activella, Afirmelle, Alyacen 1/35, Amethia, Amethia Lo, Amethyst, Angeliq, Apri, Aranelle, Ashlyna, Aubra EQ, Aurovela 1.5/30, Aurovela 1/20, Aurovela 24 Fe, Aurovela Fe 1/20, Aviane, Ayuna, Azurette, BLISOVI FE 1.5/30, BLISOVI FE 1/20, BRIELLYN, Balcoltra, Balziva, Bekyree, Beyaz, Bijuva, Blisovi 24 Fe, Blisovi Fe 1.5/30, Blisovi Fe 1/20, Brevicon, CHATEAL, CRYSELLE, CYCLESSA, CYRED, Camrese, Caziant, Charlotte 24Fe, Chateal EQ, Cryselle, Cyclafem 1/35, Cyclafem 7/7/7, Cyonanz, Cyred EQ, DESOGESTREL AND ETHINYL ESTRADIOL, DESOGESTREL AND ETHINYL ESTRADIOL AND ETHINYL ESTRADIOL, DROSPIRENONE AND ETHINYL ESTRADIOL, DROSPIRENONE, ETHINYL ESTRADIOL AND LEVOMEFOLATE CALCIUM AND LEVOMEFOLATE CALCIUM, Dasetta 1/35, Dasetta 7/7/7, Daysee, Delyla, Desogen, Desogestrel and Ethinyl Estradiol, Drospirenone and Ethinyl Estradiol, Drospirenone and ethinyl estradiol, Drospirenone/Ethinyl Estradiol/Levomefolate Calcium and Levomefolate Calcium, Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium, EMOQUETTE, ENPRESSE, ENSKYCE, ESTRADIOL AND NORETHINDRONE ACETATE, ESTRADIOL VAGINAL INSERTS, ESTROSTEP Fe, ETHYNODIOL DIACETATE AND ETHINYL ESTRADIOL, Elinest, Emoquette, Enpresse, Estarylla, Estrace, Estradiol / Norethindrone Acetate, Estradiol Valerate and Estradiol Valerate/Dienogest, Estradiol and Norethindrone Acetate, FAYOSIM, FEMCON Fe, Falessa, Falmina, Femynor, Fyavolv, GENERESS Fe, GIANVI, GILDESS FE 1.5/30, GILDESS FE 1/20, Gianvi, Gildagia, Gildess 1.5/30, Gildess 1/20, Gildess 24 Fe, HAILEY Fe 1/20, HGH Vitality, Hailey 1.5/30, Hailey 24 Fe, Hailey Fe 1.5/30, Iclevia, Introvale, Isibloom, JAIMIESS, JINTELI, Jasmiel, Jevantique Lo, Jinteli, Jolessa, Juleber, Junel, Junel 1.5/30, Junel Fe, Junel Fe 1.5/30, Junel Fe 1/20, KARIVA, Kaitlib Fe, Kalliga, Kariva, Kelnor 1/35, Kelnor 1/50, Kimidess, Kurvelo, LEVONEST, LEVONORGESTREL AND ETHINYL ESTRADIOL, LEVONORGESTREL AND ETHINYL ESTRADIOL AND ETHINYL ESTRADIOL, LO/OVRAL-28, LOESTRIN 1.5/30, LOESTRIN 1/20, LOESTRIN Fe 1.5/30, LOESTRIN Fe 1/20, LOPREEZA, LORYNA, Larin 1.5/30, Larin 1/20, Larin 24 Fe, Larin Fe 1.5/30, Larin Fe 1/20, Larissia, Layolis Fe, Leena, Lessina, Levlite, Levonest, Levonorgestrel and Ethinyl Estradiol, Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol, Levora, Lillow, Lo Loestrin Fe, Lo Minastrin Fe, Lo Simpesse, Lo-Zumandimine, Lo/Ovral-28, LoJaimiess, LoSeasonique, Loestrin, Loestrin 24 Fe, Lomedia 24 Fe, Lopreeza, Loryna, Low-Ogestrel, Lutera, Lybrel, MARLISSA, MERCILON, MICROGESTIN 1.5/30, MICROGESTIN 1/20, MICROGESTIN Fe 1.5/30, MICROGESTIN Fe 1/20, MINIVLAR 30, MYVLAR, Melodetta 24 Fe, Mibelas 24 Fe, Microgestin, Microgestin 24 Fe, Microgestin Fe, Mili, Mimvey, Mimvey Lo, Minastrin 24 Fe, Mircette, Modicon, Mono-Linyah, MonoNessa, Myzilra, NECON 1/35, NORETHINDRONE ACETATE AND ETHINYL ESTRADIOL, NORETHINDRONE ACETATE AND ETHINYL ESTRADIOL AND FERROUS FUMARATE, NORETHINDRONE AND ETHINYL ESTRADIOL AND FERROUS FUMARATE, NORGESTIMATE AND ETHINYL ESTRADIOL, Natazia, Necon, Necon 0.5/35, Necon 1/35, Necon 10/11, Necon 777, Nexesta Fe, Nikki, Nordette, Norethindrone Acetate and Ethinyl Estradiol, Norethindrone Acetate and Ethinyl Estradiol and Ferrous Fumarate, Norethindrone and Ethinyl Estradiol and Ferrous Fumarate, Norgestimate and Ethinyl Estradiol, Norgestimate and ethinyl estradiol, Norgestrel/Ethinyl Estradiol, Norinyl, Nortrel, Nortrel 7/7/7, Nylia 1/35, Nylia 7/7/7, OCELLA, ORTHO TRI CYCLEN Lo, OVCON 35, Ogestrel, Oriahnn, Orsythia, Ortho Cept, Ortho Cyclen, Ortho Novum, Ortho Tri Cyclen, Ortho-Novum, PIMTREA, PIRMELLA 1/35, PIRMELLA 7/7/7, Philith, Portia, Prefest, Previfem, QUARTETTE, Quasense, RAJANI, Reclipsen, Rivelsa, SETLAKIN, SIMLIYA, SRONYX, Safyral, Seasonique, Simpesse, Solia, Sprintec, Sronyx, Syeda, TARINA 24 FE, TARINA Fe 1/20, TRI-LO-MARZIA, Tarina Fe 1/20 EQ, Taytulla, Tilia Fe, Tri Femynor, Tri Previfem, Tri-Estarylla, Tri-Legest Fe, Tri-Linyah, Tri-Lo- Estarylla, Tri-Lo-Mili, Tri-Lo-Sprintec, Tri-Mili, Tri-Norinyl, Tri-Previfem, Tri-Sprintec, Tri-VyLibra, Tri-VyLibra Lo, TriNessa, TriNessa Lo, Trivora, Tydemy, VIORELE, Vagifem, Velivet, Vestura, Vienva TM, Volnea, VyLibra, Vyfemla, WYMZYA FE, WYMZYA Fe, Wera, YUVAFEM, Yasmin, Yaz, Yuvafem, ZEOSA, Zarah, Zenchent, Zenchent 0.4/35, Zenchent FE, Zovia 1/35, Zovia 1/35E-28, Zovia 1/50E-28, Zumandimine, camrese Lo, desogestrel and ethinyl estradiol, drospirenone and ethinyl estradiol, femhrt, levonorgestrel and ethinyl estradiol, norethindrone acetate and ethinyl estradiol and ferrous fumarate, norgestimate and ethinyl estradiol, EstroGel, ESTRADIOL, Estradiol, Estradiol Vaginal Cream, Estradiol Transdermal System, Estradiol Gel, ESTROGEN PHENOLIC, ESTRACE, Estradiol Vaginal, DOTTI, estradiol, Climara, DIVIGEL, Estrogen 4X, LYLLANA, Minivelle, ELESTRIN, Vivelle-Dot, Evamist, Estring, Menostar, Estradiol 1557, ESTRADIOL VAGINAL

Boxed warning

WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA Estrogen-Alone Therapy Endometrial Cancer There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding [see WARNINGS, Malignant Neoplasms, Endometrial Cancer ]. Cardiovascular Disorders and Probable Dementia Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia [see CLINICAL STUDIES and WARNINGS, Cardiovascular Disorders, and Probable Dementia ]. The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg]-alone, relative to placebo [see CLINICAL STUDIES and WARNINGS, Cardiovascular Disorders ]. The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE (0.625 mg)-alone, relative to placebo. It is unknown whether this finding applies to younger postmenopausal women [see CLINICAL STUDIES and WARNINGS, Probable Dementia and PRECAUTIONS, Geriatric Use ]. In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and other dosage forms of estrogens. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. Estrogen Plus Progestin Therapy Cardiovascular Disorders and Probable Dementia Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia [see CLINICAL STUDIES and WARNINGS, Cardiovascular Disorders, and Probable Dementia ]. The WHI estrogen plus progestin substudy reported increased risks of DVT, pulmonary embolism (PE), stroke and myocardial infarction (MI) in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral CE (0.625 mg) combined with medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo [see CLINICAL STUDIES and WARNINGS, Cardiovascular Disorders ]. The WHIMS estrogen plus progestin ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with daily CE (0.625 mg) combined with MPA (2.5 mg), relative to placebo. It is unknown whether this finding applies to younger postmenopausal women [see CLINICAL STUDIES and WARNINGS, Probable Dementia and PRECAUTIONS, Geriatric Use ]. Breast Cancer The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer [see CLINICAL STUDIES and WARNINGS, Malignant Neoplasms, Breast Cancer ]. In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA, and other combinations and dosage forms of estrogens and progestins. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

Warnings

BOXED WARNING: "ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER" in women with a uterus, with risk related to dose and duration of use; "close clinical surveillance of all women taking estrogens is important." The label also states "estrogens with or without progestins should not be used for the prevention of cardiovascular disease," citing Women's Health Initiative findings of "increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis" and an increased risk of dementia in women 65 and older. Contraindications include undiagnosed abnormal genital bleeding, known or suspected breast cancer, active or history of DVT/PE or arterial thromboembolic disease, liver dysfunction, known or suspected pregnancy, and known hypersensitivity.

Contraindications

CONTRAINDICATIONS Estradiol Vaginal Cream, 0.01% should not be used in women with any of the following conditions: Undiagnosed abnormal genital bleeding. Known, suspected, or history of cancer of the breast. Known or suspected estrogen-dependent neoplasia. Active DVT, PE or history of these conditions. Active arterial thromboembolic disease (for example, stroke, MI) or a history of these conditions. Known anaphylactic reaction or angioedema to Estradiol Vaginal Cream, 0.01%. Known liver dysfunction or disease. Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders. Known or suspected pregnancy.

Overdose

OVERDOSAGE Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of Estradiol Vaginal Cream, 0.01% therapy together with institution of appropriate symptomatic care.

Drug interactions

D. Drug-Laboratory Test Interactions Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of anti-factor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity. Increased thyroid-binding globulin (TBG) leading to increased circulating total thyroid hormone levels, as measured by protein-bound iodine (PBI), T 4 levels (by column or by radioimmunoassay) or T 3 levels by radioimmunoassay. T 3 resin uptake is decreased, reflecting the elevated TBG. Free T 4 and free T 3 concentrations are unaltered. Women on thyroid replacement therapy may require higher dose of thyroid hormone. Other binding proteins may be elevated in serum, i.e., corticosteroid binding globulin (CBG), sex hormone-binding globulin (SHBG), leading to increased total circulating corticosteroids and sex steroids, respectively. Free hormone concentrations, such as testosterone and estradiol, may be decreased. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin). Increased plasma high-density lipoprotein (HDL) and HDL 2 cholesterol subfraction concentrations, reduced low-density lipoprotein (LDL) cholesterol concentration, increased triglycerides levels. Impaired glucose tolerance.

Uses

Indicated for treatment of moderate to severe vasomotor symptoms (hot flashes) and moderate to severe vulvar and vaginal atrophy associated with menopause; treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure; palliative treatment of certain cases of metastatic breast cancer and advanced androgen-dependent prostate cancer; and prevention of postmenopausal osteoporosis.

Dosage forms & strengths

Capsule Capsule, Gelatin Coated Capsule, Liquid Filled Tablet Tablet, Chewable Tablet, Coated Tablet, Film Coated TABLET GEL PATCH POWDER LIQUID CREAM FILM, EXTENDED RELEASE PATCH, EXTENDED RELEASE GEL, METERED INSERT SPRAY TABLET, FILM COATED SYSTEM

ANHYDROUS LACTOSE 81.35 mg STARCH, CORN 12.5 mg POVIDONE K30 3 mg CROSPOVIDONE, UNSPECIFIED 2.5 mg Magnesium Stearate 0.5 mg CHASTE TREE 6 [hp_X] AMBERGRIS 6 [hp_X] APIOLE (PARSLEY) 6 [hp_X] ESTRADIOL 6 [hp_X] ESTRIOL 6 [hp_X] LEVODOPA 6 [hp_X] MELATONIN 6 [hp_X] TESTOSTERONE 6 [hp_X] ADENOSINE TRIPHOSPHATE DISODIUM 8 [hp_X] .ALPHA.-LIPOIC ACID 8 [hp_X] NADIDE 8 [hp_X] PANTOTHENIC ACID 8 [hp_X] LACTIC ACID, L- 8 [hp_X] UBIDECARENONE 8 [hp_X] BARIUM CARBONATE 8 [hp_X] CONIUM MACULATUM FLOWERING TOP 8 [hp_X] SELENIUM 8 [hp_X] ESTRONE 8 [hp_X] SUS SCROFA UMBILICAL CORD 30 [hp_X] SUS SCROFA ADRENAL GLAND 30 [hp_X] PORK LIVER 30 [hp_X] SUS SCROFA HYPOTHALAMUS 30 [hp_X] SUS SCROFA LYMPH 30 [hp_X] SUS SCROFA BONE MARROW 30 [hp_X] SUS SCROFA OVARY 30 [hp_X] SUS SCROFA TESTICLE 30 [hp_X] SUS SCROFA PANCREAS 30 [hp_X] SUS SCROFA SPLEEN 30 [hp_X] SOMATROPIN 30 [hp_X] PROTEUS MORGANII 30 [hp_C] CONIUM MACULATUM FLOWERING TOP 6 [hp_X] ESTRONE 6 [hp_X] COENZYME A 8 [hp_X] DESOGESTREL 0.1 mg ETHINYL ESTRADIOL 0.025 mg DESOGESTREL 0.125 mg DESOGESTREL 0.15 mg ETHINYL ESTRADIOL 0.02 mg ETHINYL ESTRADIOL 0.03 mg DROSPIRENONE 3 mg LEVOMEFOLATE CALCIUM 0.451 mg Drospirenone 3 mg Ethinyl Estradiol 0.02 mg Ethinyl Estradiol 0.03 mg ELAGOLIX SODIUM 300 mg NORETHINDRONE 0.5 mg ESTRADIOL 1 mg ESTRADIOL 0.5 mg DROSPIRENONE 0.25 mg NORETHINDRONE 0.1 mg NORETHINDRONE ACETATE 0.1 mg DROSPIRENONE 0.5 mg NORETHINDRONE ACETATE 0.5 mg NORGESTIMATE 0.09 mg ESTRADIOL 10 ug HYPROMELLOSES 54.212 mg ESTRADIOL 2 mg ESTRADIOL HEMIHYDRATE 10 ug ESTRADIOL VALERATE 1 mg ESTRADIOL VALERATE 2 mg DIENOGEST 2 mg DIENOGEST 3 mg ESTRADIOL VALERATE 3 mg ETHINYL ESTRADIOL .01 mg ETHINYL ESTRADIOL 0.0025 mg ETHINYL ESTRADIOL 0.005 mg NORETHINDRONE ACETATE 1 mg ETHINYL ESTRADIOL 0.01 mg LEVONORGESTREL 0.1 mg NORETHINDRONE 0.8 mg NORGESTIMATE 0.18 mg NORGESTIMATE 0.215 mg NORGESTIMATE 0.25 mg LEVONORGESTREL 0.05 mg LEVONORGESTREL 0.125 mg LEVONORGESTREL 0.15 mg NORETHINDRONE ACETATE 1.5 mg NORGESTREL 0.3 mg ETHINYL ESTRADIOL 0.035 mg NORETHINDRONE 0.4 mg NORETHINDRONE 0.75 mg NORETHINDRONE 1 mg ETHINYL ESTRADIOL 0.04 mg LEVONORGESTREL 0.075 mg ETHINYL ESTRADIOL 10 ug ETHINYL ESTRADIOL 20 ug ETHINYL ESTRADIOL 30 ug ETHINYL ESTRADIOL 50 ug ETHYNODIOL DIACETATE 1 mg ETHINYL ESTRADIOL 35 ug Estradiol 0.5 mg Norethindrone Acetate 0.1 mg Estradiol 1 mg Norethindrone Acetate 0.5 mg FERROUS FUMARATE 75 mg GESTODENE 0.075 mg LEVOMEFOLATE CALCIUM 0.451 1 LEVONORGESTREL 0.050 mg ETHINYL ESTRADIOL 0.030 mg ETHINYL ESTRADIOL 0.040 mg LEVONORGESTREL 0.1 MILLIGRAM in 1 TABLET / ETHINYL ESTRADIOL 0.02 MILLIGRAM in 1 TABLET LEVONORGESTREL 0.1 mg / ETHINYL ESTRADIOL 0.02 mg Lactose Monohydrate 63.58 mg STARCH, CORN 15.5 mg POVIDONE K30 3.4 mg CROSPOVIDONE, UNSPECIFIED 3.5 mg LEVONORGESTREL 0.15 mg / ETHINYL ESTRADIOL 0.03 mg LEVONORGESTREL 90 ug / ETHINYL ESTRADIOL 20 ug LEVONORGESTREL 90 ug Levonorgestrel 0.05 mg Levonorgestrel 0.075 mg Ethinyl Estradiol 0.04 mg Levonorgestrel 0.1 mg Levonorgestrel 0.125 mg NORETHINDRONE .5 mg ETHINYL ESTRADIOL .035 mg NORETHINDRONE ACETATE 0.4 mg ETHINYL ESTRADIOL 2.5 ug ETHINYL ESTRADIOL .02 mg ETHINYL ESTRADIOL 5 ug NORETHINDRONE ACETATE 1.0 mg NORGESTIMATE 0.180 mg NORGESTIMATE 0.250 mg NORGESTREL 0.3 mg / ETHINYL ESTRADIOL 0.03 mg NORGESTREL 0.5 mg ETHINYL ESTRADIOL 0.05 mg Norethindrone 0.5 mg Ethinyl Estradiol 0.035 mg Norethindrone 1 mg Ethinyl Estradiol 0.0025 mg Norethindrone Acetate 1 mg Ethinyl Estradiol 0.005 mg Ethinyl Estradiol 20 ug Norgestimate 0.18 mg Norgestimate 0.215 mg Norgestimate 0.25 mg desogestrel 0.1 mg ethinyl estradiol 0.025 mg desogestrel 0.125 mg desogestrel 0.15 mg / ethinyl estradiol 0.03 mg desogestrel 0.15 mg ethinyl estradiol 0.03 mg estradiol 1 mg progesterone 100 mg norethindrone 0.5 mg ethinyl estradiol 0.035 mg norethindrone 0.75 mg norethindrone 1 mg norgestimate 0.18 mg norgestimate 0.180 mg norgestimate 0.215 mg norgestimate 0.25 mg ESTRADIOL .5 mg/1 ESTRADIOL .25 mg/.25g ESTRADIOL 1 mg/1 ESTRADIOL .05 mg/d ESTRADIOL .06 mg/d ESTRADIOL 1 kg/1 ESTRADIOL 1 mg/g ESTRADIOL 1.25 mg/1.25g ESTRADIOL 6 [hp_X]/mL ESTRADIOL .1 mg/g ESTRADIOL .0375 mg/d ESTRADIOL .075 mg/d ESTRADIOL .025 mg/d ESTRADIOL .1 mg/d ESTRADIOL .5 mg/.5g ESTRADIOL .75 mg/1.25g ESTRADIOL .75 mg/.75g ESTRADIOL 4 ug/1 ESTRADIOL 1 g/g ESTRADIOL .006 g/g ESTRADIOL 2 mg/1 ESTRADIOL .014 mg/d ESTRADIOL 4 [hp_X]/mL ESTRADIOL 10 ug/1 ESTRADIOL .52 mg/.87g ESTRADIOL HEMIHYDRATE .1 mg/g ESTRADIOL .004 g/g ESTRADIOL 1 kg/kg ESTRADIOL 1.53 mg/1 ESTRADIOL HEMIHYDRATE 1 kg/kg ESTRADIOL 14 ug/d ESTRADIOL HEMIHYDRATE 10 ug/1 ESTRIOL 1 g/g ESTRADIOL 9 [hp_X]/29.5mL

DOSAGE AND ADMINISTRATION Use of Estradiol Vaginal Cream, 0.01% alone or in combination with a progestin, should be limited to the shortest duration consistent with treatment goals and risks for the individual woman. Postmenopausal women should reevaluate periodically as clinically appropriate to determine if treatment is still necessary. For treatment of vulvar and vaginal atrophy associated with the menopause, the lowest dose and regimen that will control symptoms should be chosen and medication should be discontinued as promptly as possible. For women who have a uterus, adequate diagnostic measures, including directed and random endometrial sampling when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal genital bleeding. Usual Dosage: The usual dosage range is 2 to 4 g (marked on the applicator) daily for one or two weeks, then gradually reduced to one half initial dosage for a similar period. A maintenance dosage of 1 g, one to three times a week, may be used after restoration of the vaginal mucosa has been achieved. NOTE: The number of doses per tube will vary with dosage requirements and patient handling.

Ingredients

Active:

ACTIVE INGREDIENT: (in each drop): 24.98% of Estradiol 12X, 30X, 12C, 30C; 0.10% of Estradiol 6X.

Inactive:

INACTIVE INGREDIENTS: Demineralized water, 20% Ethanol.