Divalproex

Brand names: DIVALPROEX SODIUM, DIVALPROEX SODIUM DELAYED-RELEASE, DIVALPROEX SODIUM EXTENDED-RELEASE, Depakote, Divalproex Sodium, Divalproex Sodium Delayed Release, Divalproex Sodium Extended Release, Divalproex Sodium Extended-Release, Divalproex SodiumDelayed-Release, Divalproex sodium, divalproex sodium

Warnings

BOXED WARNING describing three life-threatening risks. Hepatotoxicity: "hepatic failure resulting in fatalities has occurred... usually during the first six months of treatment," with children under two and patients with mitochondrial disorders at greatest risk. Fetal risk: "valproate can cause major congenital malformations, particularly neural tube defects" and "decreased IQ scores and neurodevelopmental disorders following in utero exposure," so it should not be used for migraine prophylaxis in pregnant women or those of childbearing potential unless no alternative is acceptable. Pancreatitis: "life-threatening pancreatitis... some described as hemorrhagic with rapid progression from initial symptoms to death." Contraindicated in hepatic disease, known urea cycle disorders, known POLG-related mitochondrial disorders, and in pregnancy for migraine prevention.

Uses

Divalproex sodium is indicated for: "treatment of the manic episodes associated with bipolar disorder," "monotherapy and adjunctive therapy of complex partial seizures" and simple and complex absence seizures, and "prophylaxis of migraine headaches."

Dosage forms & strengths

C42896 C42997 Capsule Capsule, Delayed Release Tablet, Delayed Release Tablet, Extended Release Tablet, Film Coated Tablet, Film Coated, Extended Release

DIVALPROEX SODIUM 125 mg DIVALPROEX SODIUM 250 mg DIVALPROEX SODIUM 500 1 DIVALPROEX SODIUM 500 mg Divalproex Sodium 125 mg Divalproex Sodium 250 mg Divalproex Sodium 500 mg Divalproex sodium 250 mg Divalproex sodium 500 mg VALPROIC ACID 125 mg VALPROIC ACID 250 mg VALPROIC ACID 500 mg Valproic Acid 125 mg divalproex sodium 125 mg divalproex sodium 250 mg divalproex sodium 500 mg

All identified pills

MYLAN 8008

PURPLE;WHITE CAPSULE · Divalproex

2 manufacturers

Divalproex

Warnings

Uses

Dosage forms & strengths

All identified pills

Side effects

Official source