Divalproex
Brand names: DIVALPROEX SODIUM, DIVALPROEX SODIUM DELAYED-RELEASE, DIVALPROEX SODIUM EXTENDED-RELEASE, Depakote, Divalproex Sodium, Divalproex Sodium Delayed Release, Divalproex Sodium Extended Release, Divalproex Sodium Extended-Release, Divalproex SodiumDelayed-Release, Divalproex sodium, divalproex sodium
Warnings
BOXED WARNING describing three life-threatening risks. Hepatotoxicity: "hepatic failure resulting in fatalities has occurred... usually during the first six months of treatment," with children under two and patients with mitochondrial disorders at greatest risk. Fetal risk: "valproate can cause major congenital malformations, particularly neural tube defects" and "decreased IQ scores and neurodevelopmental disorders following in utero exposure," so it should not be used for migraine prophylaxis in pregnant women or those of childbearing potential unless no alternative is acceptable. Pancreatitis: "life-threatening pancreatitis... some described as hemorrhagic with rapid progression from initial symptoms to death." Contraindicated in hepatic disease, known urea cycle disorders, known POLG-related mitochondrial disorders, and in pregnancy for migraine prevention.
Uses
Divalproex sodium is indicated for: "treatment of the manic episodes associated with bipolar disorder," "monotherapy and adjunctive therapy of complex partial seizures" and simple and complex absence seizures, and "prophylaxis of migraine headaches."
Dosage forms & strengths
All identified pills
2705 V
RED OVAL · Divalproex
2706 V
ORANGE OVAL · Divalproex
3 manufacturers
2707 V
PINK OVAL · Divalproex
3 manufacturers
511
WHITE OVAL · Divalproex
512
BROWN OVAL · Divalproex
512
BROWN OVAL · Divalproex
513
BLUE OVAL · Divalproex
513
BLUE OVAL · Divalproex
691
WHITE OVAL · Divalproex
3 manufacturers
692
WHITE OVAL · Divalproex
3 manufacturers
796
PINK OVAL · Divalproex
8 manufacturers
797
ORANGE OVAL · Divalproex
10 manufacturers
798
PINK OVAL · Divalproex
12 manufacturers
93 7441
PINK OVAL · Divalproex
4 manufacturers
93 7439
BROWN OVAL · Divalproex
93 7440
BROWN OVAL · Divalproex
973
WHITE ROUND · Divalproex
2 manufacturers
A510
WHITE OVAL · Divalproex
3 manufacturers
A511
WHITE OVAL · Divalproex
7 manufacturers
A514
YELLOW OVAL · Divalproex
AN 757
WHITE CAPSULE · Divalproex
6 manufacturers
AN 755
WHITE ROUND · Divalproex
3 manufacturers
D 84
PINK OVAL · Divalproex
4 manufacturers
D 86
PINK OVAL · Divalproex
5 manufacturers
D 84
ORANGE OVAL · Divalproex
3 manufacturers
D 85
ORANGE OVAL · Divalproex
7 manufacturers
DV 125
WHITE;BLUE CAPSULE · Divalproex
HC
GRAY OVAL · Divalproex
4 manufacturers
HF
WHITE OVAL · Divalproex
2 manufacturers
I49
WHITE OVAL · Divalproex
7 manufacturers
I50
GRAY OVAL · Divalproex
11 manufacturers
L 005
PINK OVAL · Divalproex
L005
PINK OVAL · Divalproex
L005
PURPLE OVAL · Divalproex
L006
PINK OVAL · Divalproex
L006
PURPLE OVAL · Divalproex
L006
PURPLE OVAL · Divalproex
3 manufacturers
L007
PINK OVAL · Divalproex
3 manufacturers
L007
PURPLE OVAL · Divalproex
4 manufacturers
L088
WHITE OVAL · Divalproex
L089
GRAY OVAL · Divalproex
M 177
WHITE ROUND · Divalproex
8 manufacturers
M 177
WHITE ROUND · Divalproex
M 943
BLUE ROUND · Divalproex
M 944
BLUE ROUND · Divalproex
5 manufacturers
M 473
WHITE OVAL · Divalproex
10 manufacturers
M 473
WHITE OVAL · Divalproex
M945
BLUE OVAL · Divalproex
3 manufacturers
Side effects
Most common adverse reactions, reported in 15% or more of patients in at least one indication, include "abdominal pain, alopecia, asthenia, diarrhea, diplopia, dizziness, headache, infection, insomnia, nausea, somnolence, thrombocytopenia, tremor, vomiting." Other notable risks include hyperammonemia and, as with other antiepileptic drugs, increased risk of suicidal thoughts or behavior.